That is strainge. Are you on the latest BIOS/UEFI version to be sure it its not a known bug?Do you have serial console or VGA output that shows a panic or similar messages?Have you tweaked or modified sysctls?
I would reset all tweaks to default and test if the system is stable again.If it is, you know something with the changed option has bad a bad side effect.Thats how I would try to find the problem.