I think this part is not needed:
At least disabling it solved my problem
https://forum.opnsense.org/index.php?topic=39717.0
Quotehttps://docs.opnsense.org/manual/how-tos/wireguard-s2s.html
Step 4a - Setup Firewall Site A
Go to Firewall ‣ Settings ‣ Normalization and add a new rule to prevent fragmentation of traffic going through the wireguard tunnel.
At least disabling it solved my problem
https://forum.opnsense.org/index.php?topic=39717.0