I added a static route from 10.10.10.54/32 to the WAN gateway ("WAN_DHCP") under System > Routes > Configuration. Then I made my VPN gateway the default gateway by lowering its priority to 250. When I do that, I lose connectivity.
<your wireguard peer>/32 --> <your ISP upstream gateway>
Note that setting explicit outgoing interfaces only works when they are statically configured.