Issue with AdGuard General Settings-DNS Time Out

[mush2020]

I have installed AdGuard with Unbound enabled.

In AdGuard-General Settings, 

Use AdGuard browsing security web service

Use AdGuard parental  control web service

single or both enabled, clients get DNS time out.

Under DNS settings - Upstream DNS servers are added IPs of Opnsese LAN and Wifi Interfaces and loopback:5353

Encryption settings not enabled so far

How to remove or add listening interfaces that were added during initial setup.

anyone can help to resolve this issue.