192.168.100.1 is a common cable modem management address. If the DOCSIS side of the cable modem goes out, the modem will assign your WAN an address in the 192.168.100.x range, typically with a 30 second lease. This is done so you will still have IP connectivity to the modem management interface.So, just be sure you really want to block this expected behavior.
Yes, there could be unintended routing issues if you have full 192.168.0.0/16 address range within your LAN. Then it would be a local route and not pass to the WAN.