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I had a different situation....my OPNSense setup is a virtual machine, but is NOT my primary gateway for the network.   And had a different route for the LAN interface.   AS it was expecting itself to be the router.   I had to add a secondary gateway (unmonitored as I couldn't get it to say it was healthy in a timely manner)   I then set up the LAN interface to use the network's Gateway then suddenly I could access my internal network as expected.   As others had suggested, I did a tcpdump on an internal address (I had to hop through my opnsense server to do it) and I only saw the inbound connection and it wouldn't return to the client on the other end.

tcpdump -i <LAN> <wg subnet>

So basically, you can't expect two ends of the network to talk to each other without a common gateway in the middle.

LAN should have a manual GATEWAY configured for your internal network.   Hope this helps someone who comes across this.