I should add that I have multiqueue enabled in the virtio NICs on the Proxmox host. The following are tunings that I've done to try to stabilize the box.
kern.timecounter.hardware=ACPI-fast
net.isr.maxthreads=8
net.isr.numthreads=8
net.isr.dispatch= deferred
hw.vtnet.lro_disable=1
hw.vtnet.tso_disable=1
hw.vtnet.csum_disable=1
kern.timecounter.hardware=ACPI-fast
net.isr.maxthreads=8
net.isr.numthreads=8
net.isr.dispatch= deferred
hw.vtnet.lro_disable=1
hw.vtnet.tso_disable=1
hw.vtnet.csum_disable=1