I have the wireGuard server setup using the official OPNsense docs, and everything works just fine except I cant access any of my own sites that sit behind my NGINX Proxy Manager when I am connected to the VPN.
I also have Adguard Home setup which then goes through unbound on OPNsense.
If I enable "NAT Reflection" I can access my local URLs from my LAN, but I still cant access then when I'm connected through WireGuard.
My Wireguard network is listed in the Access Lists for Unbound. And if I open the Adguard UI I can see normal DNS queries going through just fine.
I'd be happy to post any screenshots or other info, I just didnt want to flood my op with a ton of stuff that may not have been needed.